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Indoxyl sulfate reduces I(to,f) by activating ROS/MAPK and NF-κB signaling pathways
There is a high prevalence of ventricular arrhythmias related to sudden cardiac death in patients with chronic kidney disease (CKD). To explored the possible mechanism of CKD-related ventricular arrhythmias, a CKD rat model was created, and indoxyl sulfate (IS) was further used in vivo and in vitro....
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855797/ https://www.ncbi.nlm.nih.gov/pubmed/35132967 http://dx.doi.org/10.1172/jci.insight.145475 |