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Regulation of the double-stranded RNA response through ADAR1 licenses metaplastic reprogramming in gastric epithelium

Cells recognize both foreign and host-derived double-stranded RNA (dsRNA) via a signaling pathway that is usually studied in the context of viral infection. It has become increasingly clear that the sensing and handling of endogenous dsRNA is also critical for cellular differentiation and developmen...

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Detalles Bibliográficos
Autores principales: Sáenz, José B., Vargas, Nancy, Cho, Charles J., Mills, Jason C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855806/
https://www.ncbi.nlm.nih.gov/pubmed/35132959
http://dx.doi.org/10.1172/jci.insight.153511