Epac1(–/–) and Epac2(–/–) mice exhibit deficient epithelial Na(+) channel regulation and impaired urinary Na(+) conservation

Exchange proteins directly activated by cAMP (Epacs) are abundantly expressed in the renal tubules. We used genetic and pharmacological tools in combination with balance, electrophysiological, and biochemical approaches to examine the role of Epac1 and Epac2 in renal sodium handling. We demonstrate...

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Detalles Bibliográficos
Autores principales: Tomilin, Viktor N., Pyrshev, Kyrylo, Stavniichuk, Anna, Hassanzadeh Khayyat, Naghmeh, Ren, Guohui, Zaika, Oleg, Khedr, Sherif, Staruschenko, Alexander, Mei, Fang C., Cheng, Xiaodong, Pochynyuk, Oleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855822/
https://www.ncbi.nlm.nih.gov/pubmed/34914636
http://dx.doi.org/10.1172/jci.insight.145653

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855822/
https://www.ncbi.nlm.nih.gov/pubmed/34914636
http://dx.doi.org/10.1172/jci.insight.145653

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