The Purkinje–myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmia syndrome caused by gene mutations that render RYR2 Ca release channels hyperactive, provoking spontaneous Ca release and delayed afterdepolarizations (DADs). What remains unknown is the cellular source of ventricular arrhy...

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Detalles Bibliográficos
Autores principales: Blackwell, Daniel J., Faggioni, Michela, Wleklinski, Matthew J., Gomez-Hurtado, Nieves, Venkataraman, Raghav, Gibbs, Chelsea E., Baudenbacher, Franz J., Gong, Shiaoching, Fishman, Glenn I., Boyle, Patrick M., Pfeifer, Karl, Knollmann, Bjorn C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855823/
https://www.ncbi.nlm.nih.gov/pubmed/34990403
http://dx.doi.org/10.1172/jci.insight.151893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855823/
https://www.ncbi.nlm.nih.gov/pubmed/34990403
http://dx.doi.org/10.1172/jci.insight.151893

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