The interaction of secreted phospholipase A(2)-IIA with the microbiota alters its lipidome and promotes inflammation

Secreted phospholipase A(2)-IIA (sPLA(2)-IIA) hydrolyzes phospholipids to liberate lysophospholipids and fatty acids. Given its poor activity toward eukaryotic cell membranes, its role in the generation of proinflammatory lipid mediators is unclear. Conversely, sPLA(2)-IIA efficiently hydrolyzes bac...

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Detalles Bibliográficos
Autores principales: Doré, Etienne, Joly-Beauparlant, Charles, Morozumi, Satoshi, Mathieu, Alban, Lévesque, Tania, Allaeys, Isabelle, Duchez, Anne-Claire, Cloutier, Nathalie, Leclercq, Mickaël, Bodein, Antoine, Payré, Christine, Martin, Cyril, Petit-Paitel, Agnes, Gelb, Michael H., Rangachari, Manu, Murakami, Makoto, Davidovic, Laetitia, Flamand, Nicolas, Arita, Makoto, Lambeau, Gérard, Droit, Arnaud, Boilard, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855825/
https://www.ncbi.nlm.nih.gov/pubmed/35076027
http://dx.doi.org/10.1172/jci.insight.152638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855825/
https://www.ncbi.nlm.nih.gov/pubmed/35076027
http://dx.doi.org/10.1172/jci.insight.152638

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