Cargando…
Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in mice
Cellular and molecular mechanisms driving morbidity following SARS-CoV-2 infection have not been well defined. The receptor for advanced glycation end products (RAGE) is a central mediator of tissue injury and contributes to SARS-CoV-2 disease pathogenesis. In this study, we temporally delineated ke...
Autores principales: | Jessop, Forrest, Schwarz, Benjamin, Scott, Dana, Roberts, Lydia M., Bohrnsen, Eric, Hoidal, John R., Bosio, Catharine M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Clinical Investigation
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855831/ https://www.ncbi.nlm.nih.gov/pubmed/35076028 http://dx.doi.org/10.1172/jci.insight.155896 |
Ejemplares similares
-
Route of Francisella tularensis infection informs spatiotemporal metabolic reprogramming and inflammation in mice
por: Jessop, Forrest, et al.
Publicado: (2023) -
Targeting 2-Oxoglutarate–Dependent Dioxygenases Promotes Metabolic Reprogramming That Protects against Lethal SARS-CoV-2 Infection in the K18-hACE2 Transgenic Mouse Model
por: Jessop, Forrest, et al.
Publicado: (2023) -
Effective inhibition of HCoV-OC43 and SARS-CoV-2 by phytochemicals in vitro and in vivo.
por: Ojha, Durbadal, et al.
Publicado: (2023) -
Combined molnupiravir-nirmatrelvir treatment improves the inhibitory effect on SARS-CoV-2 in macaques
por: Rosenke, Kyle, et al.
Publicado: (2023) -
Combined Molnupiravir and Nirmatrelvir Treatment Improves the Inhibitory Effect on SARS-CoV-2 in Rhesus Macaques
por: Rosenke, Kyle, et al.
Publicado: (2022)