Group IIA secreted phospholipase A(2) controls skin carcinogenesis and psoriasis by shaping the gut microbiota

Besides promoting inflammation by mobilizing lipid mediators, group IIA secreted phospholipase A(2) (sPLA(2)-IIA) prevents bacterial infection by degrading bacterial membranes. Here, we show that, despite the restricted intestinal expression of sPLA(2)-IIA in BALB/c mice, its genetic deletion leads...

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Detalles Bibliográficos
Autores principales: Miki, Yoshimi, Taketomi, Yoshitaka, Kidoguchi, Yuh, Yamamoto, Kei, Muramatsu, Kazuaki, Nishito, Yasumasa, Park, Jonguk, Hosomi, Koji, Mizuguchi, Kenji, Kunisawa, Jun, Soga, Tomoyoshi, Boilard, Eric, B. Gowda, Siddabasave Gowda, Ikeda, Kazutaka, Arita, Makoto, Murakami, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855835/
https://www.ncbi.nlm.nih.gov/pubmed/35076024
http://dx.doi.org/10.1172/jci.insight.152611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8855835/
https://www.ncbi.nlm.nih.gov/pubmed/35076024
http://dx.doi.org/10.1172/jci.insight.152611

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