Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis

There is a growing appreciation for the idea that bacterial utilization of host-derived lipids, including cholesterol, supports Mycobacterium tuberculosis (Mtb) pathogenesis. This has generated interest in identifying novel antibiotics that can disrupt cholesterol utilization by Mtb in vivo. Here we...

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Detalles Bibliográficos
Autores principales: Wilburn, Kaley M., Montague, Christine R., Qin, Bo, Woods, Ashley K., Love, Melissa S., McNamara, Case W., Schultz, Peter G., Southard, Teresa L., Huang, Lu, Petrassi, H. Michael, VanderVen, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856561/
https://www.ncbi.nlm.nih.gov/pubmed/35134095
http://dx.doi.org/10.1371/journal.ppat.1009862

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856561/
https://www.ncbi.nlm.nih.gov/pubmed/35134095
http://dx.doi.org/10.1371/journal.ppat.1009862

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