Ultra-sensitive AAV capsid detection by immunocapture-based qPCR following factor VIII gene transfer

Adeno-associated virus (AAV)-based gene therapy vectors are replication-incompetent and thus pose minimal risk for horizontal transmission or release into the environment. In studies with AAV5-FVIII-SQ (valoctocogene roxaparvovec), an investigational gene therapy for hemophilia A, residual vector DN...

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Detalles Bibliográficos
Autores principales: Sandza, Krystal, Clark, Annie, Koziol, Elli, Akeefe, Hassibullah, Yang, Fan, Holcomb, Jennifer, Patton, Kathryn, Hammon, Kevin, Mitchell, Nina, Wong, Wing Y., Zoog, Stephen J., Kim, Benjamin, Henshaw, Joshua, Vettermann, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856957/
https://www.ncbi.nlm.nih.gov/pubmed/34421119
http://dx.doi.org/10.1038/s41434-021-00287-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8856957/
https://www.ncbi.nlm.nih.gov/pubmed/34421119
http://dx.doi.org/10.1038/s41434-021-00287-1

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