High-pH structure of EmrE reveals the mechanism of proton-coupled substrate transport

The homo-dimeric bacterial membrane protein EmrE effluxes polyaromatic cationic substrates in a proton-coupled manner to cause multidrug resistance. We recently determined the structure of substrate-bound EmrE in phospholipid bilayers by measuring hundreds of protein-ligand H(N)–F distances for a fl...

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Detalles Bibliográficos
Autores principales: Shcherbakov, Alexander A., Spreacker, Peyton J., Dregni, Aurelio J., Henzler-Wildman, Katherine A., Hong, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857205/
https://www.ncbi.nlm.nih.gov/pubmed/35181664
http://dx.doi.org/10.1038/s41467-022-28556-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857205/
https://www.ncbi.nlm.nih.gov/pubmed/35181664
http://dx.doi.org/10.1038/s41467-022-28556-6

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