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ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1
Inhibition of the master growth regulator mTORC1 (mechanistic target of rapamycin complex 1) slows ageing across phyla, in part by reducing protein synthesis. Various stresses globally suppress protein synthesis through the integrated stress response (ISR), resulting in preferential translation of t...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857226/ https://www.ncbi.nlm.nih.gov/pubmed/35181679 http://dx.doi.org/10.1038/s41467-022-28599-9 |