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ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

Inhibition of the master growth regulator mTORC1 (mechanistic target of rapamycin complex 1) slows ageing across phyla, in part by reducing protein synthesis. Various stresses globally suppress protein synthesis through the integrated stress response (ISR), resulting in preferential translation of t...

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Detalles Bibliográficos
Autores principales:	Statzer, Cyril, Meng, Jin, Venz, Richard, Bland, Monet, Robida-Stubbs, Stacey, Patel, Krina, Petrovic, Dunja, Emsley, Raffaella, Liu, Pengpeng, Morantte, Ianessa, Haynes, Cole, Mair, William B., Longchamp, Alban, Filipovic, Milos R., Blackwell, T. Keith, Ewald, Collin Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857226/ https://www.ncbi.nlm.nih.gov/pubmed/35181679 http://dx.doi.org/10.1038/s41467-022-28599-9

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