GM-CSF drives myelopoiesis, recruitment and polarisation of tumour-associated macrophages in cholangiocarcinoma and systemic blockade facilitates antitumour immunity

OBJECTIVE: Intrahepatic cholangiocarcinoma (iCCA) is rising in incidence, and at present, there are limited effective systemic therapies. iCCA tumours are infiltrated by stromal cells, with high prevalence of suppressive myeloid populations including tumour-associated macrophages (TAMs) and myeloid-...

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Detalles Bibliográficos
Autores principales: Ruffolo, Luis I, Jackson, Katherine M, Kuhlers, Peyton C, Dale, Benjamin S, Figueroa Guilliani, Nathania M, Ullman, Nicholas A, Burchard, Paul R, Qin, Shuyang S, Juviler, Peter G, Keilson, Jessica Millian, Morrison, Ashley B, Georger, Mary, Jewell, Rachel, Calvi, Laura M, Nywening, Timothy M, O'Dell, Michael R, Hezel, Aram F, De Las Casas, Luis, Lesinski, Gregory B, Yeh, Jen Jen, Hernandez-Alejandro, Roberto, Belt, Brian A, Linehan, David C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Hepatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857285/
https://www.ncbi.nlm.nih.gov/pubmed/34413131
http://dx.doi.org/10.1136/gutjnl-2021-324109

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857285/
https://www.ncbi.nlm.nih.gov/pubmed/34413131
http://dx.doi.org/10.1136/gutjnl-2021-324109

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