Efficient genome editing in Claviceps purpurea using a CRISPR/Cas9 ribonucleoprotein method

Claviceps purpurea produces many pharmacologically important ergot alkaloids (EAS), which are widely used to treat migraine and hypertension and to aid childbirth. Although an EAS biosynthetic cluster of C. purpurea has been discovered more than 20 years ago, the complete biosynthetic pathway of EAS...

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Detalles Bibliográficos
Autores principales: Yu, Lu, Xiao, Meili, Zhu, Zhihua, Wang, Yinmei, Zhou, Zhihua, Wang, Pingping, Zou, Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857428/
https://www.ncbi.nlm.nih.gov/pubmed/35224234
http://dx.doi.org/10.1016/j.synbio.2022.02.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857428/
https://www.ncbi.nlm.nih.gov/pubmed/35224234
http://dx.doi.org/10.1016/j.synbio.2022.02.002

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