Structural basis of T cell receptor specificity and cross-reactivity of two HLA-DQ2.5-restricted gluten epitopes in celiac disease

Celiac disease is a T cell-mediated chronic inflammatory condition often characterized by human leukocyte antigen (HLA)-DQ2.5 molecules presenting gluten epitopes derived from wheat, barley, and rye. Although some T cells exhibit cross-reactivity toward distinct gluten epitopes, the structural basis...

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Detalles Bibliográficos
Autores principales: Ciacchi, Laura, Farenc, Carine, Dahal-Koirala, Shiva, Petersen, Jan, Sollid, Ludvig M., Reid, Hugh H., Rossjohn, Jamie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857473/
https://www.ncbi.nlm.nih.gov/pubmed/35065967
http://dx.doi.org/10.1016/j.jbc.2022.101619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857473/
https://www.ncbi.nlm.nih.gov/pubmed/35065967
http://dx.doi.org/10.1016/j.jbc.2022.101619

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