Immunosuppressive calcineurin inhibitor cyclosporine A induces proapoptotic endoplasmic reticulum stress in renal tubular cells

Current immunosuppressive strategies in organ transplantation rely on calcineurin inhibitors cyclosporine A (CsA) or tacrolimus (Tac). Both drugs are nephrotoxic, but CsA has been associated with greater renal damage than Tac. CsA inhibits calcineurin by forming complexes with cyclophilins, whose ch...

Descripción completa

Detalles Bibliográficos
Autores principales: Yilmaz, Duygu Elif, Kirschner, Karin, Demirci, Hasan, Himmerkus, Nina, Bachmann, Sebastian, Mutig, Kerim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857494/
https://www.ncbi.nlm.nih.gov/pubmed/35033536
http://dx.doi.org/10.1016/j.jbc.2022.101589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857494/
https://www.ncbi.nlm.nih.gov/pubmed/35033536
http://dx.doi.org/10.1016/j.jbc.2022.101589

Ejemplares similares