Immunosuppressive calcineurin inhibitor cyclosporine A induces proapoptotic endoplasmic reticulum stress in renal tubular cells

Current immunosuppressive strategies in organ transplantation rely on calcineurin inhibitors cyclosporine A (CsA) or tacrolimus (Tac). Both drugs are nephrotoxic, but CsA has been associated with greater renal damage than Tac. CsA inhibits calcineurin by forming complexes with cyclophilins, whose ch...

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Detalles Bibliográficos
Autores principales: Yilmaz, Duygu Elif, Kirschner, Karin, Demirci, Hasan, Himmerkus, Nina, Bachmann, Sebastian, Mutig, Kerim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857494/
https://www.ncbi.nlm.nih.gov/pubmed/35033536
http://dx.doi.org/10.1016/j.jbc.2022.101589

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