Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease

Endosomal anomalies because of vesicular traffic impairment have been indicated as an early pathology of Alzheimer’| disease (AD). However, the mechanisms and therapeutic targets remain unclear. We previously reported that βCTF, one of the pathogenic metabolites of APP, interacts with TMEM30A. TMEM3...

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Detalles Bibliográficos
Autores principales: Kaneshiro, Nanaka, Komai, Masato, Imaoka, Ryosuke, Ikeda, Atsuya, Kamikubo, Yuji, Saito, Takashi, Saido, Takaomi C., Tomita, Taisuke, Hashimoto, Tadafumi, Iwatsubo, Takeshi, Sakurai, Takashi, Uehara, Takashi, Takasugi, Nobumasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857600/
https://www.ncbi.nlm.nih.gov/pubmed/35243232
http://dx.doi.org/10.1016/j.isci.2022.103869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857600/
https://www.ncbi.nlm.nih.gov/pubmed/35243232
http://dx.doi.org/10.1016/j.isci.2022.103869

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