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Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease

Endosomal anomalies because of vesicular traffic impairment have been indicated as an early pathology of Alzheimer’| disease (AD). However, the mechanisms and therapeutic targets remain unclear. We previously reported that βCTF, one of the pathogenic metabolites of APP, interacts with TMEM30A. TMEM3...

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Detalles Bibliográficos
Autores principales:	Kaneshiro, Nanaka, Komai, Masato, Imaoka, Ryosuke, Ikeda, Atsuya, Kamikubo, Yuji, Saito, Takashi, Saido, Takaomi C., Tomita, Taisuke, Hashimoto, Tadafumi, Iwatsubo, Takeshi, Sakurai, Takashi, Uehara, Takashi, Takasugi, Nobumasa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857600/ https://www.ncbi.nlm.nih.gov/pubmed/35243232 http://dx.doi.org/10.1016/j.isci.2022.103869

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