Competitively disrupting the neutrophil-specific receptor–autoantigen CD177:proteinase 3 membrane complex reduces anti-PR3 antibody-induced neutrophil activation

CD177 is a neutrophil-specific receptor presenting the proteinase 3 (PR3) autoantigen on the neutrophil surface. CD177 expression is restricted to a neutrophil subset, resulting in CD177(pos)/mPR3(high) and CD177(neg)/mPR3(low) populations. The CD177(pos)/mPR3(high) subset has implications for antin...

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Detalles Bibliográficos
Autores principales: Marino, Stephen F., Jerke, Uwe, Rolle, Susanne, Daumke, Oliver, Kettritz, Ralph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857647/
https://www.ncbi.nlm.nih.gov/pubmed/35063507
http://dx.doi.org/10.1016/j.jbc.2022.101598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8857647/
https://www.ncbi.nlm.nih.gov/pubmed/35063507
http://dx.doi.org/10.1016/j.jbc.2022.101598

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