PINK1-parkin-mediated neuronal mitophagy deficiency in prion disease

A persistent accumulation of damaged mitochondria is part of prion disease pathogenesis. Normally, damaged mitochondria are cleared via a major pathway that involves the E3 ubiquitin ligase parkin and PTEN-induced kinase 1 (PINK1) that together initiate mitophagy, recognize and eliminate damaged mit...

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Detalles Bibliográficos
Autores principales: Li, Jie, Lai, Mengyu, Zhang, Xixi, Li, Zhiping, Yang, Dongming, Zhao, Mengyang, Wang, Dongdong, Sun, Zhixin, Ehsan, Sharjeel, Li, Wen, Gao, Hongli, Zhao, Deming, Yang, Lifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858315/
https://www.ncbi.nlm.nih.gov/pubmed/35184140
http://dx.doi.org/10.1038/s41419-022-04613-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858315/
https://www.ncbi.nlm.nih.gov/pubmed/35184140
http://dx.doi.org/10.1038/s41419-022-04613-2

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