Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence

During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce senescence and reduce tumour growth in breast cancer patients. However, even though can...

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Detalles Bibliográficos
Autores principales: Carpintero-Fernández, Paula, Borghesan, Michela, Eleftheriadou, Olga, Pan-Castillo, Belen, Fafián-Labora, Juan Antonio, Mitchell, Tom P., Yuste, Alejandro, Ogrunc, Muge, Nightingale, Thomas D., Mayan, Maria, O’Loghlen, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858321/
https://www.ncbi.nlm.nih.gov/pubmed/35184131
http://dx.doi.org/10.1038/s41419-022-04569-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858321/
https://www.ncbi.nlm.nih.gov/pubmed/35184131
http://dx.doi.org/10.1038/s41419-022-04569-3

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