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Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence
During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce senescence and reduce tumour growth in breast cancer patients. However, even though can...
Autores principales: | Carpintero-Fernández, Paula, Borghesan, Michela, Eleftheriadou, Olga, Pan-Castillo, Belen, Fafián-Labora, Juan Antonio, Mitchell, Tom P., Yuste, Alejandro, Ogrunc, Muge, Nightingale, Thomas D., Mayan, Maria, O’Loghlen, Ana |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858321/ https://www.ncbi.nlm.nih.gov/pubmed/35184131 http://dx.doi.org/10.1038/s41419-022-04569-3 |
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