Cucurbitacin B inhibits TGF-β1-induced epithelial–mesenchymal transition (EMT) in NSCLC through regulating ROS and PI3K/Akt/mTOR pathways

BACKGROUND: Lung cancer is the leading cause of cancer mortality worldwide, and most of the patients after treatment with EGF-TKIs develop drug resistance, which is closely correlated with EMT. Cucurbitacin B (CuB) is a natural product of the Chinese herb Cucurbitaceae plant, which has a favorable r...

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Detalles Bibliográficos
Autores principales: Yuan, Renyikun, Fan, Qiumei, Liang, Xiaowei, Han, Shan, He, Jia, Wang, Qin-Qin, Gao, Hongwei, Feng, Yulin, Yang, Shilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858510/
https://www.ncbi.nlm.nih.gov/pubmed/35183200
http://dx.doi.org/10.1186/s13020-022-00581-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858510/
https://www.ncbi.nlm.nih.gov/pubmed/35183200
http://dx.doi.org/10.1186/s13020-022-00581-z

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