ACSS3 in brown fat drives propionate catabolism and its deficiency leads to autophagy and systemic metabolic dysfunction

Propionate is a gut microbial metabolite that has been reported to have controversial effects on metabolic health. Here we show that propionate is activated by acyl‐CoA synthetase short‐chain family member 3 (ACSS3), located on the mitochondrial inner membrane in brown adipocytes. Knockout of Acss3...

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Detalles Bibliográficos
Autores principales: Jia, Zhihao, Chen, Xiyue, Chen, Jingjuan, Zhang, Lijia, Oprescu, Stephanie N., Luo, Nanjian, Xiong, Yan, Yue, Feng, Kuang, Shihuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858619/
https://www.ncbi.nlm.nih.gov/pubmed/35184387
http://dx.doi.org/10.1002/ctm2.665

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858619/
https://www.ncbi.nlm.nih.gov/pubmed/35184387
http://dx.doi.org/10.1002/ctm2.665

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