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ACSS3 in brown fat drives propionate catabolism and its deficiency leads to autophagy and systemic metabolic dysfunction
Propionate is a gut microbial metabolite that has been reported to have controversial effects on metabolic health. Here we show that propionate is activated by acyl‐CoA synthetase short‐chain family member 3 (ACSS3), located on the mitochondrial inner membrane in brown adipocytes. Knockout of Acss3...
Autores principales: | Jia, Zhihao, Chen, Xiyue, Chen, Jingjuan, Zhang, Lijia, Oprescu, Stephanie N., Luo, Nanjian, Xiong, Yan, Yue, Feng, Kuang, Shihuan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8858619/ https://www.ncbi.nlm.nih.gov/pubmed/35184387 http://dx.doi.org/10.1002/ctm2.665 |
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