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Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis

BACKGROUND: Debate on the potential carcinogenic effects of meat intake is open and the relationship between meat consumption and risk of prostate cancer remains uncertain. This meta-analysis was conducted to summarize earlier prospective studies on the association of meat consumption with risk of p...

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Autores principales: Nouri-Majd, Saeedeh, Salari-Moghaddam, Asma, Aminianfar, Azadeh, Larijani, Bagher, Esmaillzadeh, Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859108/
https://www.ncbi.nlm.nih.gov/pubmed/35198587
http://dx.doi.org/10.3389/fnut.2022.801722
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author Nouri-Majd, Saeedeh
Salari-Moghaddam, Asma
Aminianfar, Azadeh
Larijani, Bagher
Esmaillzadeh, Ahmad
author_facet Nouri-Majd, Saeedeh
Salari-Moghaddam, Asma
Aminianfar, Azadeh
Larijani, Bagher
Esmaillzadeh, Ahmad
author_sort Nouri-Majd, Saeedeh
collection PubMed
description BACKGROUND: Debate on the potential carcinogenic effects of meat intake is open and the relationship between meat consumption and risk of prostate cancer remains uncertain. This meta-analysis was conducted to summarize earlier prospective studies on the association of meat consumption with risk of prostate cancer. METHODS: Relevant studies were identified by exploring PubMed/Medline, Scopus, Web of Science, EMBASE, and Google Scholar databases up to December 2020. Fixed-effects and random-effects meta-analyses were used for pooling the relative risks (RRs). Heterogeneity across studies was evaluated using the Q-statistic and I-square (I(2)). A funnel plot and Egger's test was used to detect publication bias. Linear and non-linear dose-response analyses were performed to estimate the dose-response relations between meat intake and risk of prostate cancer. RESULTS: Twenty-five prospective studies were included in this meta-analysis. Totally, 1,900,910 participants with 35,326 incident cases of prostate cancer were investigated. Pooling the eligible effect sizes, we observed that high consumption of processed meat might be associated with an increased risk of “total prostate cancer” (RR: 1.06; 95% CI: 1.01, 1.10; I(2) = 1.5%, P = 0.43) and “advanced prostate cancer” (1.17; 1.09, 1.26; I(2) = 58.8%, P = 0.01). However, the association between processed meat and “advanced prostate cancer” was not significant in the random-effects model: 1.12 (95% CI: 0.98, 1.29). A linear dose-response analysis indicated that an increment of 50 grams per day of processed meat intake might be related to a 4% greater risk of “total prostate cancer” (1.04; 1.00, 1.08; I(2) = 0.0%, P = 0.51). “Total meat intake” was marginally associated with all outcomes of prostate cancer risk (1.04; 1.01, 1.07; I(2) = 58.4%, P < 0.001). CONCLUSIONS: This systematic review and meta-analysis of prospective studies indicated that increased consumption of “total meat” and “processed meat” might be associated with a higher risk of prostate cancer. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=230824, identifier: CRD42021230824.
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spelling pubmed-88591082022-02-22 Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis Nouri-Majd, Saeedeh Salari-Moghaddam, Asma Aminianfar, Azadeh Larijani, Bagher Esmaillzadeh, Ahmad Front Nutr Nutrition BACKGROUND: Debate on the potential carcinogenic effects of meat intake is open and the relationship between meat consumption and risk of prostate cancer remains uncertain. This meta-analysis was conducted to summarize earlier prospective studies on the association of meat consumption with risk of prostate cancer. METHODS: Relevant studies were identified by exploring PubMed/Medline, Scopus, Web of Science, EMBASE, and Google Scholar databases up to December 2020. Fixed-effects and random-effects meta-analyses were used for pooling the relative risks (RRs). Heterogeneity across studies was evaluated using the Q-statistic and I-square (I(2)). A funnel plot and Egger's test was used to detect publication bias. Linear and non-linear dose-response analyses were performed to estimate the dose-response relations between meat intake and risk of prostate cancer. RESULTS: Twenty-five prospective studies were included in this meta-analysis. Totally, 1,900,910 participants with 35,326 incident cases of prostate cancer were investigated. Pooling the eligible effect sizes, we observed that high consumption of processed meat might be associated with an increased risk of “total prostate cancer” (RR: 1.06; 95% CI: 1.01, 1.10; I(2) = 1.5%, P = 0.43) and “advanced prostate cancer” (1.17; 1.09, 1.26; I(2) = 58.8%, P = 0.01). However, the association between processed meat and “advanced prostate cancer” was not significant in the random-effects model: 1.12 (95% CI: 0.98, 1.29). A linear dose-response analysis indicated that an increment of 50 grams per day of processed meat intake might be related to a 4% greater risk of “total prostate cancer” (1.04; 1.00, 1.08; I(2) = 0.0%, P = 0.51). “Total meat intake” was marginally associated with all outcomes of prostate cancer risk (1.04; 1.01, 1.07; I(2) = 58.4%, P < 0.001). CONCLUSIONS: This systematic review and meta-analysis of prospective studies indicated that increased consumption of “total meat” and “processed meat” might be associated with a higher risk of prostate cancer. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=230824, identifier: CRD42021230824. Frontiers Media S.A. 2022-02-07 /pmc/articles/PMC8859108/ /pubmed/35198587 http://dx.doi.org/10.3389/fnut.2022.801722 Text en Copyright © 2022 Nouri-Majd, Salari-Moghaddam, Aminianfar, Larijani and Esmaillzadeh. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Nouri-Majd, Saeedeh
Salari-Moghaddam, Asma
Aminianfar, Azadeh
Larijani, Bagher
Esmaillzadeh, Ahmad
Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis
title Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis
title_full Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis
title_fullStr Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis
title_full_unstemmed Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis
title_short Association Between Red and Processed Meat Consumption and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis
title_sort association between red and processed meat consumption and risk of prostate cancer: a systematic review and meta-analysis
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859108/
https://www.ncbi.nlm.nih.gov/pubmed/35198587
http://dx.doi.org/10.3389/fnut.2022.801722
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