CD137 Agonists Targeting CD137-Mediated Negative Regulation Show Enhanced Antitumor Efficacy in Lung Cancer

Negative immune regulation plays a notable role in tumor immunity. This study aimed to confirm that CD137 mediates negative immunoregulation as well as agonist activity in tumor immunity. Soluble CD137 (sCD137), a prominent splice variant of membrane-bound CD137 (mCD137), was identified, and its con...

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Detalles Bibliográficos
Autores principales: Yi, Ling, Jin, Xin, Wang, Jinghui, Yan, Zhuohong, Cheng, Xu, Wen, Tao, Yang, Bin, Wang, Xiaojue, Che, Nanying, Liu, Zhidong, Zhang, Hongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859117/
https://www.ncbi.nlm.nih.gov/pubmed/35197968
http://dx.doi.org/10.3389/fimmu.2022.771809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859117/
https://www.ncbi.nlm.nih.gov/pubmed/35197968
http://dx.doi.org/10.3389/fimmu.2022.771809

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