A53 A NOVEL PH-SENSITIVE OPIOID ANALOGUE PROVIDES SUSTAINED ANALGESIA DURING COLONIC INFLAMMATION AND LACKS COMMON SIDE EFFECTS

BACKGROUND: Opioids provide effective pain relief during flares of inflammatory bowel disease but are limited by serious side effects. We showed that acute administration of a novel pH-sensitive opioid agonist, NFEPP, had potent analgesic effects in inflamed acidified colonic tissues without opioid...

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Detalles Bibliográficos
Autores principales: Degro, C E, Jiménez-Vargas, N N, Tsang, Q K, Yu, Y, Stein, C, Bunnett, N W, Lomax, A E, Reed, D E, Vanner, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Poster of Distinction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859131/
http://dx.doi.org/10.1093/jcag/gwab049.052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859131/
http://dx.doi.org/10.1093/jcag/gwab049.052

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