A184 REPURPOSING DRUGS FOR SPLEEN TYROSINE KINASE (SYK) PEDIATRIC PATIENTS USING HIGH-THROUGHPUT SCREENING

BACKGROUND: Spleen Tyrosine Kinase (SYK) is a cytosolic, non-receptor tyrosine kinase with an imperative role in immune and non-immune processes. Recently, we identified six gain-of-function SYK variants in patients that presented multi-organ inflammation and immune dysregulation. The SYK variants d...

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Detalles Bibliográficos
Autores principales: Chau, S, Jardine, S, Guo, C, Warner, N, Muise, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Poster of Distinction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859165/
http://dx.doi.org/10.1093/jcag/gwab049.183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859165/
http://dx.doi.org/10.1093/jcag/gwab049.183

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