Preclinical safety profile of a liver-localized mitochondrial uncoupler: OPC-163493

Mitochondrial uncouplers (mUncouplers) are known to exhibit a variety of toxic effects in animals. Here we report a safety profile of an mUncoupler, OPC-163493, recently synthesized at Otsuka Pharmaceutical Co, Ltd, and its development as a therapeutic agent for treating diabetes. To understand the...

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Detalles Bibliográficos
Autores principales: Inoue, Yuki, Kino, Junichi, Ishiharada, Nobuya, Sato, Makoto, Hatanaka, Suguru, Yokoi, Hiroyuki, Shimada, Takahiro, Sato, Seiji, Okamoto, Takashi, Kanemoto, Naohide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859645/
https://www.ncbi.nlm.nih.gov/pubmed/35221841
http://dx.doi.org/10.17179/excli2021-4414

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859645/
https://www.ncbi.nlm.nih.gov/pubmed/35221841
http://dx.doi.org/10.17179/excli2021-4414

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