Concise Six-Step Asymmetric Approach to Ramelteon from an Acetophenone Derivative Using Ir, Rh, Cu, and Ni Catalysis

[Image: see text] A concise six-step asymmetric synthesis of nearly enantiomerically pure ramelteon was developed from a monocyclic precursor with a 17% overall yield and a 97% ee in the asymmetric step. The synthetically challenging tricyclic 1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan core of ramelte...

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Detalles Bibliográficos
Autores principales: Cluzeau, Jérôme, Nettekoven, Ulrike, Kovačevič, Miroslav Planinc, Časar, Zdenko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859824/
https://www.ncbi.nlm.nih.gov/pubmed/34592102
http://dx.doi.org/10.1021/acs.joc.1c01614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859824/
https://www.ncbi.nlm.nih.gov/pubmed/34592102
http://dx.doi.org/10.1021/acs.joc.1c01614

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