Cargando…

Soman (GD) Rat Model to Mimic Civilian Exposure to Nerve Agent: Mortality, Video-EEG Based Status Epilepticus Severity, Sex Differences, Spontaneously Recurring Seizures, and Brain Pathology

Modeling a real-world scenario of organophosphate nerve agent (OPNA) exposure is challenging. Military personnel are premedicated with pyridostigmine, which led to the development of OPNA models with pyridostigmine/oxime pretreatment to investigate novel therapeutics for acute and chronic effects. H...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gage, Meghan, Rao, Nikhil S., Samidurai, Manikandan, Putra, Marson, Vasanthi, Suraj S., Meyer, Christina, Wang, Chong, Thippeswamy, Thimmasettappa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859837/ https://www.ncbi.nlm.nih.gov/pubmed/35197823 http://dx.doi.org/10.3389/fncel.2021.798247

Ejemplares similares

Sex‐based structural and functional MRI outcomes in the rat brain after soman (GD) exposure‐induced status epilepticus
por: Gage, Meghan, et al.
Publicado: (2023)

DFP-Induced Status Epilepticus Severity in Mixed-Sex Cohorts of Adult Rats Housed in the Same Room: Behavioral and EEG Comparisons
por: Rao, Nikhil S., et al.
Publicado: (2022)

Disease-Modifying Effects of a Glial-targeted Inducible Nitric Oxide Synthase Inhibitor (1400W) in Mixed-sex Cohorts of a Rat Soman (GD) Model of Epilepsy
por: Vasanthi, Suraj S., et al.
Publicado: (2023)

Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy
por: Vasanthi, Suraj S., et al.
Publicado: (2023)

1400 W, a selective inducible nitric oxide synthase inhibitor, mitigates early neuroinflammation and nitrooxidative stress in diisopropylfluorophosphate-induced short-term neurotoxicity rat model
por: Massey, Nyzil, et al.
Publicado: (2023)

Peripheral and central effects of NADPH oxidase inhibitor, mitoapocynin, in a rat model of diisopropylfluorophosphate (DFP) toxicity
por: Meyer, Christina, et al.
Publicado: (2023)

Differential Impact of Severity and Duration of Status Epilepticus, Medical Countermeasures, and a Disease-Modifier, Saracatinib, on Brain Regions in the Rat Diisopropylfluorophosphate Model
por: Gage, Meghan, et al.
Publicado: (2021)

Fyn-tau Ablation Modifies PTZ-Induced Seizures and Post-seizure Hallmarks of Early Epileptogenesis
por: Putra, Marson, et al.
Publicado: (2020)

Status Epilepticus: Behavioral and Electroencephalography Seizure Correlates in Kainate Experimental Models
por: Sharma, Shaunik, et al.
Publicado: (2018)

Saracatinib, a Src Tyrosine Kinase Inhibitor, as a Disease Modifier in the Rat DFP Model: Sex Differences, Neurobehavior, Gliosis, Neurodegeneration, and Nitro-Oxidative Stress
por: Gage, Meghan, et al.
Publicado: (2021)

The effects of Src tyrosine kinase inhibitor, saracatinib, on the markers of epileptogenesis in a mixed-sex cohort of adult rats in the kainic acid model of epilepsy
por: Rao, Nikhil S., et al.
Publicado: (2023)

Characterization of Cortical Glial Scars in the Diisopropylfluorophosphate (DFP) Rat Model of Epilepsy
por: Gage, Meghan, et al.
Publicado: (2022)

A Chromogenic Probe for the Selective Recognition of Sarin and Soman Mimic DFP**
por: El Sayed, Sameh, et al.
Publicado: (2014)

Soman‐induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam
por: Marrero‐Rosado, Brenda, et al.
Publicado: (2018)

Gut dysbiosis following organophosphate, diisopropylfluorophosphate (DFP), intoxication and saracatinib oral administration
por: Gage, Meghan, et al.
Publicado: (2022)

Interleukin-18 expression increases in response to neurovascular damage following soman-induced status epilepticus in rats
por: Johnson, Erik A., et al.
Publicado: (2015)

Antiseizure and Neuroprotective Efficacy of Midazolam in Comparison with Tezampanel (LY293558) against Soman-Induced Status Epilepticus
por: Figueiredo, Taiza H., et al.
Publicado: (2022)

Seizure-Induced Oxidative Stress in Temporal Lobe Epilepsy
por: Puttachary, Sreekanth, et al.
Publicado: (2015)

Exploring the benefits of in-diet versus repeated oral dosing of saracatinib (AZD0530) in chronic studies: insights into pharmacokinetics and animal welfare
por: Vasanthi, Suraj S., et al.
Publicado: (2023)

Zr(OH)(4)/GO Nanocomposite for the Degradation of Nerve Agent Soman (GD) in High-Humidity Environments
por: Jang, Seongon, et al.
Publicado: (2020)

Behavioral side effects of prophylactic therapies against soman-induced seizures and lethality in rats
por: Myhrer, Trond, et al.
Publicado: (2014)

The acute phase response and soman-induced status epilepticus: temporal, regional and cellular changes in rat brain cytokine concentrations
por: Johnson, Erik A, et al.
Publicado: (2010)

Advantages of Repeated Low Dose against Single High Dose of Kainate in C57BL/6J Mouse Model of Status Epilepticus: Behavioral and Electroencephalographic Studies
por: Tse, Karen, et al.
Publicado: (2014)

(-)-Phenserine Attenuates Soman-Induced Neuropathology
por: Chen, Jun, et al.
Publicado: (2014)

Comparison of Binding Affinities of Water-Soluble Calixarenes with the Organophosphorus Nerve Agent Soman (GD) and Commonly-Used Nerve Agent Simulants
por: Ede, Jayne A., et al.
Publicado: (2018)

Prof. G.R. Soman (1948–2021)
por: Kale, M. G.
Publicado: (2022)

Immediate Epileptogenesis after Kainate-Induced Status Epilepticus in C57BL/6J Mice: Evidence from Long Term Continuous Video-EEG Telemetry
por: Puttachary, Sreekanth, et al.
Publicado: (2015)

Cerebral and systemic hemodynamic effect of recurring seizures
por: Ferlini, Lorenzo, et al.
Publicado: (2021)

Dataset of EEG power integral, spontaneous recurrent seizure and behavioral responses following combination drug therapy in soman-exposed rats
por: Lumley, Lucille A., et al.
Publicado: (2019)

The Impacts of Surgery and Intracerebral Electrodes in C57BL/6J Mouse Kainate Model of Epileptogenesis: Seizure Threshold, Proteomics, and Cytokine Profiles
por: Tse, Karen, et al.
Publicado: (2021)

Tribute to a maverick: Dr. Soman Rema Krishna Manohar
por: Shivaprakasha, Krishnanaik, et al.
Publicado: (2022)

Clarithromycin-induced Seizures and Status Epilepticus
por: Seetharam, Raghavendra, et al.
Publicado: (2021)

Increased expression of the chemokines CXCL1 and MIP-1α by resident brain cells precedes neutrophil infiltration in the brain following prolonged soman-induced status epilepticus in rats
por: Johnson, Erik A, et al.
Publicado: (2011)

Cocaine-Associated Seizures and Incidence of Status Epilepticus
por: Majlesi, Nima, et al.
Publicado: (2010)

Breaking the Seizure Randomness Myth: Evidence for a Recurring Ebb and Flow of Seizure Risk on the Continuum of Time
por: Punia, Vineet
Publicado: (2021)

Use of Hupresin To Capture Red Blood Cell Acetylcholinesterase for Detection of Soman Exposure
por: Onder, Seda, et al.
Publicado: (2017)

Chromo-Fluorogenic Detection of Soman and Its Simulant by Thiourea-Based Rhodamine Probe
por: Li, Shengsong, et al.
Publicado: (2019)

Soman-induced toxicity, cholinesterase inhibition and neuropathology in adult male Göttingen minipigs()
por: Lumley, Lucille, et al.
Publicado: (2021)

Electroencephalographic Seizure or Electroencephalographic Status Epilepticus in the ICU? Is it Time to Focus Just on Electroencephalographic Status Epilepticus?
por: Joshi, Charuta
Publicado: (2021)

Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine?
por: Joosen, Marloes J. A., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_9v9ec1v4dhv9jtpgqc8igola12