Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death

Pancreatic β-cells depend on the well-balanced regulation of cytosolic zinc concentrations, providing sufficient zinc ions for the processing and storage of insulin, but avoiding toxic effects. The zinc transporter ZnT8, encoded by SLC30A8,is a key player regarding islet cell zinc homeostasis, and p...

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Detalles Bibliográficos
Autores principales: Karsai, Maria, Zuellig, Richard A, Lehmann, Roger, Cuozzo, Federica, Nasteska, Daniela, Luca, Edlira, Hantel, Constanze, Hodson, David J, Spinas, Giatgen A, Rutter, Guy A, Gerber, Philipp A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859919/
https://www.ncbi.nlm.nih.gov/pubmed/35017316
http://dx.doi.org/10.1530/JOE-21-0271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859919/
https://www.ncbi.nlm.nih.gov/pubmed/35017316
http://dx.doi.org/10.1530/JOE-21-0271

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