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Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death

Pancreatic β-cells depend on the well-balanced regulation of cytosolic zinc concentrations, providing sufficient zinc ions for the processing and storage of insulin, but avoiding toxic effects. The zinc transporter ZnT8, encoded by SLC30A8,is a key player regarding islet cell zinc homeostasis, and p...

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Detalles Bibliográficos
Autores principales:	Karsai, Maria, Zuellig, Richard A, Lehmann, Roger, Cuozzo, Federica, Nasteska, Daniela, Luca, Edlira, Hantel, Constanze, Hodson, David J, Spinas, Giatgen A, Rutter, Guy A, Gerber, Philipp A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859919/ https://www.ncbi.nlm.nih.gov/pubmed/35017316 http://dx.doi.org/10.1530/JOE-21-0271

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