Synergistic Anti-Tumor Effect of Combining Selective CDK7 and BRD4 Inhibition in Neuroblastoma

PURPOSE: Cyclin-dependent kinases (CDKs) that have critical roles in RNA polymerase II (Pol II)-mediated gene transcription are emerging as therapeutic targets in cancer. We have previously shown that THZ1, a covalent inhibitor of CDKs 7/12/13, leads to cytotoxicity in MYCN-amplified neuroblastoma t...

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Detalles Bibliográficos
Autores principales: Gao, Yang, Volegova, Marina, Nasholm, Nicole, Das, Sanjukta, Kwiatkowski, Nicholas, Abraham, Brian J., Zhang, Tinghu, Gray, Nathanael S., Gustafson, Clay, Krajewska, Malgorzata, George, Rani E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859926/
https://www.ncbi.nlm.nih.gov/pubmed/35198433
http://dx.doi.org/10.3389/fonc.2021.773186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8859926/
https://www.ncbi.nlm.nih.gov/pubmed/35198433
http://dx.doi.org/10.3389/fonc.2021.773186

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