The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism

The superkiller (SKI) complex is the cytoplasmic co-factor and regulator of the RNA-degrading exosome. In human cells, the SKI complex functions mainly in co-translational surveillance-decay pathways, and its malfunction is linked to a severe congenital disorder, the trichohepatoenteric syndrome. To...

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Detalles Bibliográficos
Autores principales: Kögel, Alexander, Keidel, Achim, Bonneau, Fabien, Schäfer, Ingmar B., Conti, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860381/
https://www.ncbi.nlm.nih.gov/pubmed/35120588
http://dx.doi.org/10.1016/j.molcel.2022.01.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860381/
https://www.ncbi.nlm.nih.gov/pubmed/35120588
http://dx.doi.org/10.1016/j.molcel.2022.01.009

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