Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis

Extracellular matrix (ECM) stiffening with downstream activation of mechanosensitive pathways is strongly implicated in fibrosis. We previously reported that altered collagen nanoarchitecture is a key determinant of pathogenetic ECM structure-function in human fibrosis (Jones et al., 2018). Here, th...

Descripción completa

Detalles Bibliográficos
Autores principales: Brereton, Christopher J, Yao, Liudi, Davies, Elizabeth R, Zhou, Yilu, Vukmirovic, Milica, Bell, Joseph A, Wang, Siyuan, Ridley, Robert A, Dean, Lareb SN, Andriotis, Orestis G, Conforti, Franco, Brewitz, Lennart, Mohammed, Soran, Wallis, Timothy, Tavassoli, Ali, Ewing, Rob M, Alzetani, Aiman, Marshall, Benjamin G, Fletcher, Sophie V, Thurner, Philipp J, Fabre, Aurelie, Kaminski, Naftali, Richeldi, Luca, Bhaskar, Atul, Schofield, Christopher J, Loxham, Matthew, Davies, Donna E, Wang, Yihua, Jones, Mark G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860444/
https://www.ncbi.nlm.nih.gov/pubmed/35188460
http://dx.doi.org/10.7554/eLife.69348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860444/
https://www.ncbi.nlm.nih.gov/pubmed/35188460
http://dx.doi.org/10.7554/eLife.69348

Ejemplares similares