Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages

Interactions of developing T cells with Aire(+) medullary thymic epithelial cells expressing high levels of MHCII molecules (mTEC(hi)) are critical for the induction of central tolerance in the thymus. In turn, thymocytes regulate the cellularity of Aire(+) mTEC(hi). However, it remains unknown whet...

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Detalles Bibliográficos
Autores principales: Lopes, Noella, Boucherit, Nicolas, Santamaria, Jérémy C, Provin, Nathan, Charaix, Jonathan, Ferrier, Pierre, Giraud, Matthieu, Irla, Magali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860447/
https://www.ncbi.nlm.nih.gov/pubmed/35188458
http://dx.doi.org/10.7554/eLife.69982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860447/
https://www.ncbi.nlm.nih.gov/pubmed/35188458
http://dx.doi.org/10.7554/eLife.69982

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