Mechanisms of Cre recombinase synaptic complex assembly and activation illuminated by Cryo-EM

Cre recombinase selectively recognizes DNA and prevents non-specific DNA cleavage through an orchestrated series of assembly intermediates. Cre recombines two loxP DNA sequences featuring a pair of palindromic recombinase binding elements and an asymmetric spacer region, by assembly of a tetrameric...

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Detalles Bibliográficos
Autores principales: Stachowski, Kye, Norris, Andrew S, Potter, Devante, Wysocki, Vicki H, Foster, Mark P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860596/
https://www.ncbi.nlm.nih.gov/pubmed/35104890
http://dx.doi.org/10.1093/nar/gkac032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860596/
https://www.ncbi.nlm.nih.gov/pubmed/35104890
http://dx.doi.org/10.1093/nar/gkac032

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