Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo

A critical challenge for the successful development of RNA interference-based therapeutics therapeutics has been the enhancement of their in vivo metabolic stability. In therapeutically relevant, fully chemically modified small interfering RNAs (siRNAs), modification of the two terminal phosphodiest...

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Detalles Bibliográficos
Autores principales: Jahns, Hartmut, Taneja, Nate, Willoughby, Jennifer L S, Akabane-Nakata, Masaaki, Brown, Christopher R, Nguyen, Tuyen, Bisbe, Anna, Matsuda, Shigeo, Hettinger, Matt, Manoharan, Rajar M, Rajeev, Kallanthottathil G, Maier, Martin A, Zlatev, Ivan, Charisse, Klaus, Egli, Martin, Manoharan, Muthiah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860597/
https://www.ncbi.nlm.nih.gov/pubmed/34268578
http://dx.doi.org/10.1093/nar/gkab544

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8860597/
https://www.ncbi.nlm.nih.gov/pubmed/34268578
http://dx.doi.org/10.1093/nar/gkab544

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