Enhanced O-GlcNAc modification induced by the RAS/MAPK/CDK1 pathway is required for SOX2 protein expression and generation of cancer stem cells

Cancer stem cells (CSCs) have tumour initiation, self-renewal, and long-term tumour repopulation properties, and it is postulated that differentiated somatic cells can be reprogrammed to CSCs by oncogenic signals. We previously showed that oncogenic HRAS(V12) conferred tumour initiation capacity in...

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Detalles Bibliográficos
Autores principales: Shimizu, Masahiro, Shibuya, Hiroshi, Tanaka, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861017/
https://www.ncbi.nlm.nih.gov/pubmed/35190631
http://dx.doi.org/10.1038/s41598-022-06916-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861017/
https://www.ncbi.nlm.nih.gov/pubmed/35190631
http://dx.doi.org/10.1038/s41598-022-06916-y

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