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Specific length and structure rather than high thermodynamic stability enable regulatory mRNA stem-loops to pause translation
Translating ribosomes unwind mRNA secondary structures by three basepairs each elongation cycle. Despite the ribosome helicase, certain mRNA stem-loops stimulate programmed ribosomal frameshift by inhibiting translation elongation. Here, using mutagenesis, biochemical and single-molecule experiments...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861025/ https://www.ncbi.nlm.nih.gov/pubmed/35190568 http://dx.doi.org/10.1038/s41467-022-28600-5 |