Specific length and structure rather than high thermodynamic stability enable regulatory mRNA stem-loops to pause translation

Translating ribosomes unwind mRNA secondary structures by three basepairs each elongation cycle. Despite the ribosome helicase, certain mRNA stem-loops stimulate programmed ribosomal frameshift by inhibiting translation elongation. Here, using mutagenesis, biochemical and single-molecule experiments...

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Detalles Bibliográficos
Autores principales: Bao, Chen, Zhu, Mingyi, Nykonchuk, Inna, Wakabayashi, Hironao, Mathews, David H., Ermolenko, Dmitri N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861025/
https://www.ncbi.nlm.nih.gov/pubmed/35190568
http://dx.doi.org/10.1038/s41467-022-28600-5

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