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Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization

The complex interaction between cancer cells and the immune microenvironment is a central regulator of tumor growth and the treatment response. Chemotherapy-induced senescence is accompanied by the senescence-associated secretion phenotype (SASP). However, the mechanisms underlying the regulation of...

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Detalles Bibliográficos
Autores principales: Liu, Hao, Zhao, Dong, Li, Huayi, Zhang, Wenxin, Lin, Qingyu, Wang, Xingwen, Zheng, Shanliang, Zhang, Lei, Li, Li, Hu, Shaoshan, Hu, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861031/
https://www.ncbi.nlm.nih.gov/pubmed/35190529
http://dx.doi.org/10.1038/s41419-022-04611-4