T-cell activation decreases miRNA-15a/16 levels to promote MEK1–ERK1/2–Elk1 signaling and proliferative capacity

While miRs have been extensively studied in the context of malignancy and tumor progression, their functions in regulating T-cell activation are less clear. In initial studies, we found reduced levels of miR-15a/16 at 3 to 18 h post–T-cell receptor (TCR) stimulation, suggesting a role for decreased...

Descripción completa

Detalles Bibliográficos
Autores principales: Urena, Frank, Ma, Chi, Hoffmann, FuKun W., Nunes, Lance G.A., Urschitz, Johann, Moisyadi, Stefan, Khadka, Vedbar S., Deng, Youping, Hoffmann, Peter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861121/
https://www.ncbi.nlm.nih.gov/pubmed/35085550
http://dx.doi.org/10.1016/j.jbc.2022.101634

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861121/
https://www.ncbi.nlm.nih.gov/pubmed/35085550
http://dx.doi.org/10.1016/j.jbc.2022.101634

Ejemplares similares