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T-cell activation decreases miRNA-15a/16 levels to promote MEK1–ERK1/2–Elk1 signaling and proliferative capacity
While miRs have been extensively studied in the context of malignancy and tumor progression, their functions in regulating T-cell activation are less clear. In initial studies, we found reduced levels of miR-15a/16 at 3 to 18 h post–T-cell receptor (TCR) stimulation, suggesting a role for decreased...
Autores principales: | Urena, Frank, Ma, Chi, Hoffmann, FuKun W., Nunes, Lance G.A., Urschitz, Johann, Moisyadi, Stefan, Khadka, Vedbar S., Deng, Youping, Hoffmann, Peter R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861121/ https://www.ncbi.nlm.nih.gov/pubmed/35085550 http://dx.doi.org/10.1016/j.jbc.2022.101634 |
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