Tissue Pharmacokinetic Properties and Bystander Potential of Hypoxia-Activated Prodrug CP-506 by Agent-Based Modelling

Hypoxia-activated prodrugs are bioactivated in oxygen-deficient tumour regions and represent a novel strategy to exploit this pharmacological sanctuary for therapeutic gain. The approach relies on the selective metabolism of the prodrug under pathological hypoxia to generate active metabolites with...

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Detalles Bibliográficos
Autores principales: Jackson-Patel, Victoria, Liu, Emily, Bull, Matthew R., Ashoorzadeh, Amir, Bogle, Gib, Wolfram, Anna, Hicks, Kevin O., Smaill, Jeff B., Patterson, Adam V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861431/
https://www.ncbi.nlm.nih.gov/pubmed/35211015
http://dx.doi.org/10.3389/fphar.2022.803602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861431/
https://www.ncbi.nlm.nih.gov/pubmed/35211015
http://dx.doi.org/10.3389/fphar.2022.803602

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