Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer

Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies have shown that they increased binding affinity and signaling potency compared t...

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Detalles Bibliográficos
Autores principales: Mansoor, Samman, Kayık, Gülru, Durdagi, Serdar, Sensoy, Ozge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861583/
https://www.ncbi.nlm.nih.gov/pubmed/35242285
http://dx.doi.org/10.1016/j.csbj.2022.01.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861583/
https://www.ncbi.nlm.nih.gov/pubmed/35242285
http://dx.doi.org/10.1016/j.csbj.2022.01.016

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