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Mechanistic insight into the impact of a bivalent ligand on the structure and dynamics of a GPCR oligomer
Development of effective bivalent ligands has become the focus of intensive research toward modulation of G protein-coupled receptor (GPCR) oligomers, particularly in the field of GPCR pharmacology. Experimental studies have shown that they increased binding affinity and signaling potency compared t...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861583/ https://www.ncbi.nlm.nih.gov/pubmed/35242285 http://dx.doi.org/10.1016/j.csbj.2022.01.016 |